Silagra 100 mg Tablet

How does Silagra 100 mg work

Silagra contains Sildenafil, which belongs to a group of medicines called PDE5 inhibitors. These drugs were first studied to treat high blood pressure and chest pain. During the research, scientists discovered that they also cause erections.
Sildenafil works by stopping the PDE5 enzyme from breaking down a substance called cGMP. This molecule is essential in helping you achieve and maintain an erection. When you are sexually aroused, your body releases chemicals in the erectile tissue of your penis. These chemicals trigger the release of nitric oxide, which helps produce cGMP.
As cGMP builds up, it relaxes the smooth muscles in your blood vessels. This allows more blood to flow into your penis, resulting in an erection. By blocking the enzyme that breaks down cGMP, Silagra helps keep your erection firm and lasting longer.
While Silagra mainly targets the PDE5 enzyme, it can also affect other enzymes. This may cause side effects, which are usually related to the dosage you take. Always follow your doctor’s advice for the best results.

Uses

Erectile Dysfunction (ED)

It is a condition that is characterized by trouble getting a hard erection for sexual intercourse. Some people refer to it as “impotence.”

Benefits

• Improves erection quality, and chances of successful intercourse in men with ED,
• Builds sexual confidence,
• Increases self-esteem,
• Improves quality of life and relationships

Dosage

You should take one tablet of Silagra 100 mg in a day. Do not take more than one tablet in 24 hours. You can take Silagra with or without food. It works best on an empty stomach. Take the pill about one hour before sex.

You will feel the effects within the first hour after taking it. The effects usually last for about 4 hours, but this can vary from person to person. If you do not have erectile dysfunction, do not take this tablet unless your doctor advises you to do so.

Missed Dose

This medicine is taken when required. Therefore, you’re less likely to miss a dose.

Overdose

Overdosing can lead to various side effects. If an overdose is suspected, seek medical help immediately.

Safety Advice

Alcohol : UNSAFE
It is unsafe to drink alcohol with Silagra 100mg (sildenafil) Tablets.

Pregnancy : POSSIBLY UNSAFE
This medicine is not approved for use in women. It’s for male sexual health problems (impotence or ED).

Breastfeeding :  POSSIBLY UNSAFE
This medicine is not meant for women’s use. Information regarding the use of Sildenafil Pills during pregnancy or breastfeeding is not available. Consult your doctor for further information.

Driving : UNSAFE
This drug can make you dizzy or affect your vision. Do not drive or use hazardous machinery until you are fully aware of its effects on you.

Kidney : POSSIBLY SAFE
The medication is not known to impair kidney health. Use caution if you have severe kidney disease. Consult your doctor before taking this medicine.

Liver:  CAUTION
Silagra will be processed by your liver, so use caution if you have an existing liver problem. Consult your doctor for further advice. Your doctor will probably adjust the dosage for you.

Other Precautions

Silagra 100 mg may not suit you if you suffer from any medical condition. Before you take this medicine, let your doctor know:

• If you are allergic to Sildenafil Citrate or any other medications.
• If you have a history of stroke, congestive heart failure, etc.
• If you suffer from blood cell problems such as sickle cell anemia, leukemia, etc.
• If you suffer from kidney or liver disease.
• If you have a physical deformity of the penis or Peyronie’s.
• If you have uncontrolled blood pressure.
• If you suffer from conditions such as diabetes, high blood cholesterol, high blood pressure, etc.
• If you have a rare inherited eye condition such as retinitis pigmentosa.
• If you take nitrates for chest pain.
• If you suffer from epilepsy or seizures.
• If you are pregnant or breastfeeding.
• If you suffer from ischemic heart disease (also known as coronary artery disease).
• If you are an alcoholic or have a history of substance abuse.

If you suffer from any medical conditions not listed here, let your doctor know about them. Discuss your medical history in detail with the doctor.

Side effects

As with any other medication, there are certain side effects that can occur while taking this tablet. Most of these side effects are temporary and go away after some time.
Some common side effects include:

• Headaches
• Nausea
• Dizziness
• Flushing
• Nosebleed
• Indigestion
• Diarrhea
• Visual disturbances
• Painful urination
• Nasal congestion
• Tingling in arms and feet
• Back pain
• Some rare side effects include:
• A prolonged and painful erection of more than 4 hours (a condition known as priapism)
• Deafness
• Sudden vision loss in one or both eyes (known as NAION)
• Irregular heartbeat
• Trouble breathing

The above list shouldn’t be seen as a complete guide to side effects. If you experience any other side effects of the medication, report it to the doctor.

Drug Interactions

If you take prescription or non-prescription drugs, vitamins, and herbal supplements, let your doctor know about them. Certain medications can interact with Silagra 100 mg and alter how it works.
These include:

• Amlodipine
• Carbamazepine
• Clarithromycin
• Dexamethasone
• Imatinib Mesylate
• Ketoconazole
• Atazanavir
• Nitroglycerin
• Isoniazid
• Terazosin
• Warfarin
• Other medicines for ED
• This isn’t a complete list of potential drug interactions. Discuss possible drug interactions with your doctor before starting this medicine.

Interaction with alcohol

Alcohol increases the risk of adverse side effects and reduces the chances of getting an erection. Avoid consuming alcohol along with this medication.

Interaction with grapefruit juice

Grapefruit juice raises the levels of Silagra in the body and delays the time it takes for the medication to work. Therefore, it should not be consumed while taking this medication.

Storage Instructions

• Keep it out of the reach of children and pets.
• Keep the pills away from direct heat, moisture, and sunlight.
• Do not consume the pills past their expiration date.
• Keep the pills in a cool and dry place in an airtight container.

Substitutes Available

Aurogra 100 mg
Edegra 100 mg
Fildena 100 mg
Kamagra 100 mg
Suhagra 100 mg
Vega 100 mg

References

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• Loran OB, Ströberg P, Lee SW, Park NC, Kim SW, Tseng LJ, Collins S, Stecher VJ. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med. 2009 Oct;6(10):2826-35. doi: 10.1111/j.1743-6109.2009.01428.x. PMID: 19817982. https://www.jsm.jsexmed.org/article/S1743-6095(15)32273-6/fulltext 
• Smith BP, Babos M. Sildenafil. [Updated 2022 May 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558978/
• Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, Simonneau G; Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med. 2005 Nov 17;353(20):2148-57. doi: 10.1056/NEJMoa050010. Erratum in: N Engl J Med. 2006 Jun 1;354(22):2400-1. PMID: 16291984. https://www.nejm.org/doi/full/10.1056/NEJMoa050010 
• Sofikitis N, Kaltsas A, Dimitriadis F, Rassweiler J, Grivas N, Zachariou A, Kaponis A, Tsounapi P, Paterakis N, Karagiannis A, Skouros S, Giannakis I, Champilomatis I, Paschopoulos M, Daphnis D, Giakoumakis I, R Gabales M, M Chua JB, Lantin Iii PL, Mamoulakis C, Takenaka A. The Effect of PDE5 Inhibitors on the Male Reproductive Tract. Curr Pharm Des. 2021;27(23):2697-2713. doi: 10.2174/1381612826666200226121510. PMID: 32101115.  https://www.eurekaselect.com/article/104866
• Kim JN, Oh JJ, Park DS, Hong YK, Yu YD. Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sex Med. 2019 Dec;7(4):425-432. doi: 10.1016/j.esxm.2019.07.004. Epub 2019 Aug 20. PMID: 31444051; PMCID: PMC6963111. https://linkinghub.elsevier.com/retrieve/pii/S2050116119300935