Cenforce 150 mg

How Cenforce 150mg works

The active ingredient in Cenforce 150 mg Tablet is sildenafil citrate. It inhibits the enzyme phosphodiesterase type 5 (PDE-5). PDE-5 is the enzyme that breaks down cGMP, a messenger molecule that helps with erections. By inhibiting PDE-5, sildenafil raises the level of cGMP. This results in the relaxation of smooth muscle cells, increasing blood flow, which helps maintain a firmer and longer-lasting erection during sexual arousal.

During sexual stimulation, the blood vessel lining in the penis releases nitric oxide (NO), which triggers the production of cGMP in the smooth muscle cells of the penis. cGMP prompts the smooth muscle cells to relax. This action widens the penis’ blood vessels. The relaxation of smooth muscle cells allows for improved blood flow into the spongy tissue of the penis. This tissue is called the corpus cavernosum. The increased blood flow fills the spongy tissue, leading to an erection.

Cenforce 150 mg will not take effect if the man is not sexually aroused. Sexual stimulation (physical touch etc.) is necessary for the drug to work.

Uses of Cenforce 150mg

Cenforce 150mg is primarily used to treat erectile dysfunction (ED) in men. It helps improve blood flow to the penis, allowing men to achieve and maintain an erection during sexual activity. Cenforce is taken when sexual stimulation is expected, as it works only in response to sexual arousal.

Benefits

• Improves erection quality, and chances of successful intercourse in men with ED,
• Builds sexual confidence,
• Increases self-esteem,
• Improves quality of life and relationships

Dosage

Talk to a physician about a suitable dosage for you. The doses for ED are 50 mg and 100 mg. In severe cases where low doses do not work, the doctor may prescribe Cenforce 150. Your dose depends on other factors, e.g., any other health condition you might have/ other medications that you take.

Take the tablet about 30- 60 minutes before sexual intercourse, with a light snack. Avoid fatty food as it will prevent the drug from working quickly. The effects of this medicine last for around 4 to 6 hours.

Missed Dosage

This pill is taken as and when needed. Therefore, the chances of missing a dose are very less. If it’s time for your next scheduled dose, skip the missed dose. Consult your doctor about what should be done when a dose is missed. This pill is recommended to be taken once in 24 hours. Taking the two doses within 24 hours may lead to an overdose.

Overdose

Overdosing on an ED medication can cause serious problems. It will intensify the side effects of the drug. This may include vomiting, blurred vision, vertigo, and priapism. Priapism is a painful long erection lasting for >4 hours. Avoid overdosing on this medication at all costs. If you suspect an overdose, get emergency medical attention.

Safety Advice

Alcohol : UNSAFE
It is unsafe to drink alcohol with Cenforce 150mg (sildenafil) Tablets.

Pregnancy : POSSIBLY UNSAFE
This medicine is not approved for use in women. It’s for male sexual health problems (impotence or ED).

Breastfeeding :  POSSIBLY UNSAFE
This medicine is not meant for women’s use. Information regarding the use of Cenforce 150mg Pills during pregnancy or breastfeeding is not available. Consult your doctor for further information.

Driving : UNSAFE
This drug can make you dizzy or affect your vision. Do not drive or use hazardous machinery until you are fully aware of its effects on you.

Kidney : POSSIBLY SAFE
Sildenafil is not known to impair kidney health. Use caution if you have severe kidney disease. Consult your doctor before taking this medicine.

Liver:  CAUTION
Cenforce will be processed by your liver, so use caution if you have an existing liver problem. Consult your doctor for further advice. Your doctor will probably adjust the dosage for you. 

Precautions

People with certain health conditions should avoid taking Cenforce tablets. To avoid any adverse effects, tell your doctor about your medical history. Get a full body check-up before taking this medicine. Let your doctor know:

• If you’ve had an allergic reaction to sildenafil citrate.
• If you suffer from a heart condition, e.g., aortic stenosis and hypertrophic obstructive cardiomyopathy  
• If you suffer from Pulmonary Veno-occlusive disease (PVOD)
• If you have suffered a heart attack or angina attack before
• If your blood doesn’t coagulate quickly. Or, you have a blood-related disorder like sickle-cell anemia 
• If you take medicine to treat high blood pressure
• If you are partially or fully blind
• If your kidney and/or liver do not function normally
• If you have a deformed penis. It may be due to conditions like Peyronie’s disease or cavernosal fibrosis
• If you take blood pressure medications
• If you’ve had epileptic seizures in the past
• If you have (or had) an ulcer 
• If your doctor has advised you against having sex for some reason

Women and children must not consume Cenforce 150 mg. It should only be taken under the supervision of a doctor.

Side effects of Cenforce 150mg

While using the Cenforce, be mindful of potential side effects that may arise.

Common Side Effects:

1. Headache
2. Flushing
3. Stuffy or runny nose
4. Upset stomach
5. Changes in color vision (e.g., blue color tinge) and blurred vision
6. Back pain
7. Nausea
8. Dizziness
9. Rash
10. Muscle pain

Serious Side Effects:

1. Priapism
2. Sudden Vision Loss: Non-Arteritic Anterior Ischemic Optic Neuropathy (Naion).
3. Sudden Hearing Decrease or Loss (tinnitus) or dizziness.

Rare Side Effects (Reported in Some Men):

1. Heart attack
2. Stroke
3. Irregular heartbeats
4. Death

If you experience any severe or persistent side effects or notice any changes in your health, consult your doctor immediately.

Drugs Interactions

Some drugs can interact with Cenforce 150mg. This increases the risk of having side effects. This can also reduce the medicine’s efficacy.  Tell your doctor about all the prescription drugs and OTC medicines you are taking. Also, discuss the herbs or supplements you might be taking. Here is a list of possible drug interactions:

• Nitrate based medications
• CYP3A4 Inhibitors such as ketoconazole, itraconazole, saquinavir, etc
• Calcium channel blockers such as amlodipine
• Guanylate cyclase (GC) stimulators like Riociguat 
• Alpha-blockers such as prazosin, doxazosin, terazosin, etc
• Beta-blockers such as betaxolol, atenolol, etc
• Certain antibiotics, such as erythromycin and clarithromycin
• Mifepristone aka RU-486
• HIV protease inhibitors such as fosamprenavir
• Hepatitis C virus protease inhibitors such as telaprevir, boceprevir, etc
• Medications used to treat epilepsy, like carbamazepine
• Rifampin
• Other ED medications like Cialis, Levitra, etc
• Efavirenz

Cenforce contains sildenafil, the same active ingredient found in REVATIO. REVATIO is a medication prescribed for treating PAH. Therefore, do not use these tablets with

• REVATIO
• other PAH treatments containing sildenafil
• other PDE5 inhibitors like Vardenafil or Tadalafil.

This isn’t a complete list of potential drug interactions. Discuss possible drug interactions with your doctor before starting this medicine.

Interaction with alcohol

It is better not to consume large amounts of alcohol with Cenforce 150mg. The combination can suddenly lower your blood pressure, making you dizzy. It may also intensify the other side effects of this drug.

Interaction with grapefruit juice

Grapefruit juice raises the levels of this drug in the body and delays the time it takes for the medication to work. Therefore, it should not be consumed while taking this medication.

Storage Instructions

• Store the Cenforce 150mg tablets in their original packaging. 
• Keep them at room temperature (about 59–86° F or 15–30° C). 
• Store them away from direct sunlight, moisture, and dampness.
• Do not consume the pills if they’ve crossed the expiry date.
• Store them at a safe distance from children and pets.
• Proper disposal of empty packets and expired pills is necessary

References

1. Fink, H. A., Mac Donald, R., Rutks, I. R., Nelson, D. B., & Wilt, T. J. (2002b). Sildenafil for male erectile dysfunction. Archives of Internal Medicine, 162(12), 1349. https://doi.org/10.1001/archinte.162.12.1349
2. Smith, B. P., & Babos, M. (2023, February 14). Sildenafil. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK558978/
3. Galiè, N., Ghofrani, H. A., Torbicki, A., Barst, R. J., Rubin, L. J., Badesch, D., Fleming, T., Parpia, T., Burgess, G., Branzi, A., Grimminger, F., Kurzyna, M., & Simonneau, G. (2005). Sildenafil citrate therapy for pulmonary arterial hypertension. New England Journal of Medicine, 353(20), 2148–2157. https://doi.org/10.1056/nejmoa050010
4. Sofikitis, N., Kaltsas, A., Dimitriadis, F., Rassweiler, J., Grivas, N., Zachariou, A., Kaponis, A., Tsounapi, P., Paterakis, N., Karagiannis, A., Skouros, S., Giannakis, I., Champilomatis, I., Paschopoulos, M., Daphnis, D., Giakoumakis, I., R Gabales, M., Chua, J. B. M., Lantin, P. L., III, . . . Takenaka, A. (2021). The effect of PDE5 inhibitors on the male reproductive tract. Current Pharmaceutical Design, 27(23), 2697–2713. https://doi.org/10.2174/1381612826666200226121510
5. Kim, J. N., Oh, J. J., Park, D. S., Hong, Y. K., & Yu, Y. D. (2019). Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sexual Medicine, 7(4), 425–432. https://doi.org/10.1016/j.esxm.2019.07.004