Malegra 100mg

Manufacturer	Sunrise Remedies Pvt. Ltd.
Active Ingredient	Sildenafil citrate
Starts In	30 minutes to 1 hour
Last Long	4-6 hours
Treats	Erectile Dysfunction

How does it work?

The Malegra 100mg contains the active ingredient Sildenafil Citrate, a medicine from the PDE5 inhibitor group. The medication blocks the enzyme that breaks down cGMP, allowing blood vessels in the penis to relax and increase blood flow. This helps maintain a firmer and longer-lasting erection during sexual arousal.

During sexual stimulation, the blood vessel lining in the penis releases nitric oxide (NO), which triggers the production of cGMP in the smooth muscle cells of the penis. cGMP prompts the smooth muscle cells to relax. This action widens the penis’ blood vessels. The relaxation of smooth muscle cells allows for improved blood flow into the spongy tissue of the penis. This tissue is called the corpus cavernosum. The increased blood flow fills the spongy tissue, leading to an erection.

These pills do not directly induce an erection. Instead, it enhances the natural erectile response by amplifying penile blood flow upon sexual stimulation.

Uses

Malegra 100 mg is primarily used to treat erectile dysfunction (ED) in men. It helps improve blood flow to the penis, allowing men to achieve and maintain an erection during sexual activity. Malegra is taken when sexual stimulation is expected, as it works only in response to sexual arousal.

Dosage

Take one tablet about 30 minutes to 1 hour before sexual activity. This pill is recommended to be taken once in 24 hours. It should be taken approximately 30 minutes to 1 hour before any sexual activity. The effects of this medicine last for around 4 to 6 hours. You can consume Malegra with or without food. Taking the medication after a high-fat meal, like a cheeseburger and fries, can delay its effectiveness.

The other doses of these medicines are:

• Malegra DXT  
• Malegra FXT 
• Malegra DXT Plus 
• Malegra FXT Plus 
• Malegra 50 mg 
• Malegra 25 mg 
• Malegra Gold 100 mg 
• Malegra Green 100 mg 
• Malegra200 mg

Missed Dosage

This pill is taken as and when needed. Therefore, the chances of missing a dose are very less. If it’s time for your next scheduled dose, skip the missed dose. Consult your doctor about what should be done when a dose is missed.

Overdose

Taking more than the recommended dose of Sildenafil can increase the risk of side effects and should be avoided. Seek medical attention immediately if you experience symptoms of an overdose, such as severe dizziness, fainting, or prolonged and painful erection.

Side Effects

While using Malegra 100mg, be mindful of potential side effects that may arise.

Common Side Effects:

1. Headache
2. Flushing
3. Stuffy or runny nose
4. Upset stomach
5. Changes in color vision (e.g., blue color tinge) and blurred vision
6. Back pain
7. Nausea
8. Dizziness
9. Rash
10. Muscle pain

Serious Side Effects:

1. Priapism
2. Sudden Vision Loss: Non-Arteritic Anterior Ischemic Optic Neuropathy (Naion).
3. Sudden Hearing Decrease or Loss (tinnitus) or dizziness.

Rare Side Effects (Reported in Some Men):

1. Heart attack
2. Stroke
3. Irregular heartbeats
4. Death

If you experience any severe or persistent side effects or notice any changes in your health, consult your doctor immediately.

Important Advisory

Malegra should not be consumed by men if they have or had:

• History of stomach ulcers.
• History of liver problems.
• History of blood cell issues such as sickle cell anemia, multiple myeloma, or leukemia
• Low blood pressure
• Uncontrolled high blood pressure
• Penis with an unusual shape or Peyronie’s.
• A prolonged erection lasting more than 4 hours.
• History of heart surgery in the past 6 months.
• Pulmonary hypertension.
• A history of retinitis pigmentosa
• Bleeding problems.
• Kidney problems
• Kidney dialysis.
• Heart attack
• Irregular heartbeat
• Aortic valve narrowing
• Heart failure
• Angina (chest pain)
• Allergy from Sildenafil Citrate or any other medications.
• A history of stroke, congestive heart failure, etc.
• Suffer from conditions such as diabetes, high blood cholesterol, high blood pressure, etc.
• Take nitrates for chest pain.
• Suffer from epilepsy or seizures.
• Are pregnant or breastfeeding.
• Suffer from ischemic heart disease (also known as coronary artery disease).
• Are an alcoholic or have a history of substance abuse.

Sildenafil should only be taken under the supervision of a doctor. It should not be used by women or children.

Drug Interactions

Sildenafil may interact with other drugs, leading to side effects. Tell your doctor if you take any of the following:

1. Nitrates
2. Guanylate Cyclase Stimulators such as riociguat (Adempas).
3. Alpha Blockers like Hytrin, Flomax, Cardura, Minipress, Uroxatral, Jalyn, or Rapaflo.
4. HIV Protease Inhibitors such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase), or atazanavir sulfate (Reyataz).
5. Antifungal Medicines like ketoconazole (Nizoral) and itraconazole (Sporanox).
6. Antibiotics such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin.
7. Blood Pressure Medications
8. Other Erectile Dysfunction (ED) Treatments

Malegra contains sildenafil, the same active ingredient found in REVATIO. REVATIO is a medication prescribed for treating PAH. Therefore, do not use these tablets with

1. REVATIO
2. other PAH treatments containing sildenafil
3. other PDE5 inhibitors like Vardenafil or Tadalafil.

This isn’t a complete list of potential drug interactions. Discuss possible drug interactions with your doctor before starting this medicine.

Interaction with alcohol

Alcohol increases the risk of adverse side effects and reduces the chances of getting an erection. Avoid consuming alcohol along with this medication.

Interaction with grapefruit juice

Grapefruit juice raises the levels of this drug in the body and delays the time it takes for the medication to work. Therefore, it should not be consumed while taking this medication.

Storage Instructions

1. Keep your medications in their original containers or packaging.
2. Store them in a cool, dry place away from sunlight and moisture.
3. Make sure they’re out of reach of children and pets.
4. Check the expiration dates regularly and throw away any expired or unused medications.

Frequently Asked Questions(FAQs)

Can I take Malegra 100mg twice a day?

Malegra is recommended to be taken once in 24 hours. It should not be taken more than once in 24 hours, or you may experience severe side effects of the drug. Consult your doctor if you don’t achieve the desired results.

How long does it take for Malegra 100 mg to work?

This medicine is recommended to be taken approximately 30 minutes to 1 hour before any sexual activity. It starts to work within the first hour of its consumption. The effects can last for around 4 to 5 hours.

Is Malegra 100 mg suitable for first-time users?

Yes, it is often recommended for first-time users of erectile dysfunction medication. It’s a low dose that can be effective while minimizing the risk of potential side effects.

Can I take 100 mg of Malegra with food?

Yes, you can take the tablet with or without food. However, taking it with a heavy meal may delay its onset of action.

What should I do if I experience side effects with Malegra 100 mg?

If you experience side effects with Viagra 50 mg, such as headache, flushing, dizziness, or upset stomach, you should consult your healthcare provider.

How does Malegra 100 mg work to treat erectile dysfunction?

Malegra contains sildenafil citrate, which belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. It works by relaxing the blood vessels in the penis, allowing for increased blood flow when sexually stimulated. This helps men achieve and maintain an erection suitable for sexual activity.

 

REFERENCES

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• Sofikitis N, Kaltsas A, Dimitriadis F, Rassweiler J, Grivas N, Zachariou A, Kaponis A, Tsounapi P, Paterakis N, Karagiannis A, Skouros S, Giannakis I, Champilomatis I, Paschopoulos M, Daphnis D, Giakoumakis I, R Gabales M, M Chua JB, Lantin Iii PL, Mamoulakis C, Takenaka A. The Effect of PDE5 Inhibitors on the Male Reproductive Tract. Curr Pharm Des. 2021;27(23):2697-2713. doi: 10.2174/1381612826666200226121510. PMID: 32101115. https://www.eurekaselect.com/article/104866