Cialis 40 mg

How It Works

Cialis 40 mg works by relaxing the smooth muscles present in the walls of blood vessels. It helps to increase the blood flow throughout the body, including the penis. The production of cGMP is necessary for the dilation and contraction of blood vessels. The enzyme PDE 5 destroys cGMP and does not let the blood flow properly. Tadalafil present in Cialis 40 mg blocks the action of PDE 5 and allows cGMP to be produced properly. This allows the blood to flow to the penis. As a result, a pressure is created in the penis that leads to an erection.

Uses

Cialis 40 mg is prescribed for the treatment of the following problems:

1. Erectile Dysfunction (ED) – also known as impotence, makes it difficult for a man to achieve or maintain an erection firm enough for sexual intercourse.
2. Pulmonary Arterial Hypertension (PAH) – high blood pressure of arteries present in the lungs and right side of the heart.
3. Benign Prostatic Hyperplasia (BPH) – age-associated prostate gland enlargement that causes painful and frequent urination.

Benefits

• Improves chances of successful intercourse,
• Restores erectile function and sexual performance,
• Builds sexual confidence,
• Increases self-esteem, 
• Improves quality of life and relationships

Dosage

A single dose of Cialis 40 mg is recommended to be taken once per day. This medicine can be taken with or without food. It should be taken approximately 30 minutes to 1 hour before any sexual activity, or as directed by the doctor. The effects of this medicine can last for around 36 hours.

Missed Dose: An on-demand dosing schedule is generally followed. This means that this medicine is taken as and when needed. So, the chances of missing a dose are very less. 

However, if you take Cialis 40 mg for the treatment of Pulmonary Arterial Hypertension (PAH), you should take the missed dose as soon as possible. If it’s time for your next scheduled dose, skip the missed dose. Avoid consuming an overdose of the drug to make up for the missed dose.

Overdose: An overdose of the drug can lead to serious side effects. If you experience any side effects for long, seek medical attention immediately.

Safety Advice

Alcohol : UNSAFE
It is unsafe to drink alcohol with Cialis (Tadalafil) 40mg Tablet.

Pregnancy :SAFE IF PRESCRIBED
Your doctor may prescribe tadalafil if you have severe pulmonary hypertension. Inform your doctor as soon as possible if you are pregnant or trying to get pregnant while under this treatment. However, Cialis is not meant for women’s sexual health.

Breastfeeding : SEEK YOUR DOCTOR’S ADVICE
No confirmed data is available on the use of tadalafil during breastfeeding. Consult your doctor.

Driving : UNSAFE
This medication can make you dizzy or affect your vision. Do not drive or use hazardous machinery until you have fully understood its effects.

Kidney : CAUTION
Cialis should not be used in patients with severe kidney problems. If you have mild to moderate kidney problems, consult your healthcare provider.

Liver:  CAUTION
The medication will be processed by your liver, so use caution if you have an existing liver problem. Consult your doctor before using Cialis 40mg. . 

Other Precautions

Before you take Cialis 40 mg, tell your doctor:

1. If you take any medicines containing nitrates. Nitrates are commonly used to treat angina.
2. If you take recreational drugs called “poppers,” like amyl nitrite and butyl nitrite.
3. If you take any medicines called guanylate cyclase stimulators, such as riociguat.
4. If you are allergic to Cialis.
5. If you suffer from diseases such as diabetes, hypertension, etc.
6. If you suffer from any physical deformity of the penis.
7. If you are pregnant or breastfeeding.
8. If you suffer from retinitis pigmentosa.
9. If you have blood cell problems such as sickle cell anemia, multiple myeloma, etc.
10. If you have kidney problems or require dialysis.

Side Effects

Common side effects of Cialis 40 mg include:

• Vomiting
• Nausea
• Dizziness
• Headache
• Color blindness
• Palpitations

Some serious side effects may include:

• Sudden vision loss
• Priapism (a painful erection that lasts for more than 4 hours)
• Loss of hearing

If any of these side effects persist for long, contact your doctor immediately.

Drug Interactions

If you take any herbal, OTC, or any other form of drugs to treat your existing health condition or for any other purposes, let your doctor know about them. Certain drugs can interact with Cialis 40 mg and affect the way it works.

1. Alpha-blockers for prostate problems
2. Amlodipine
3. Carbamazepine
4. Ketoconazole
5. Phenytoin
6. Nitroglycerin
7. Cimetidine
8. Oral medicines for ED
9. Antifungal medications
10. Blood pressure medications

Interaction with alcohol

Alcohol can increase the chances of lowering your blood pressure. It can also cause some serious side effects. Avoid consuming alcohol alongside this medication.

Storage Instructions

1. Store in a cool and dry place.
2. Keep it away from the reach of children and pets.
3. Retain the medication in its original packaging.
4. Maintain the temperature as per the details on the packaging.

Substitutes Available

CIALIS 5MG

CIALIS 20 MG

CIALIS 60 MG

References

1. Coward, R., & Carson, C. (2008e). Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management, Volume 4, 1315–1329. https://doi.org/10.2147/tcrm.s3336
2. Hatzimouratidis, K. (2014). A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Therapeutic Advances in Urology, 6(4), 135–147. https://doi.org/10.1177/1756287214531639
3. Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2017b). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731–1740. https://doi.org/10.1007/s11255-017-1644-5
4. Frajese, G. V., Pozzi, F., & Frajese, G. (2006b). Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence. Clinical Interventions in Aging, 1(4), 439–449. https://doi.org/10.2147/ciia.2006.1.4.439
5. Seftel, A. D., Rosen, R. C., Hayes, R. P., Althof, S., Goldfisher, E., Shen, W., & Sontag, A. (2014). Effect of once-daily tadalafil on confidence and perceived difficulty in performing sexual intercourse in men who were incomplete responders to as-needed PDE5 inhibitor treatment. International Journal of Clinical Practice, 68(7), 841–849. https://doi.org/10.1111/ijcp.12406
6. Verheyden, B., Roumeguère, T., Bitton, A., Belger, M., & Schmitt, H. (2009). Effects of 12‐Month Tadalafil Therapy for Erectile Dysfunction on Couple Relationships: Results from the DETECT Study. The Journal of Sexual Medicine, 6(12), 3458–3468. https://doi.org/10.1111/j.1743-6109.2009.01527.x