Sildigra Super Power 160mg

How does it Work?

Sildigra Super Power 160mg tablets contain sildenafil citrate and dapoxetine. Hence, it helps in both  — activating and prolonging an erection.

To achieve and maintain an erection:

During sexual arousal, nitric oxide (NO) is released within the penis. This increases levels of another molecule called the cGMP. cGMP causes the smooth muscles inside the penis to relax.

As a result, the blood vessels open wider, allowing blood to flow. It causes the corpus cavernosa (spongy tissue in the penis) to swell. The penis becomes larger and stiff enough for sexual intercourse.

However, an enzyme called PDE5 breaks down cGMP molecules, ending the erection. PDE5 inhibitors such as sildenafil stop PDE5 from working too fast. It prevents the cGMP breakdown. It boosts the action of nitric oxide, promoting blood flow. This helps prolong the erection, making it firm enough for intercourse.   

To make the erection last longer:

Dapoxetine, on the other hand, works on the brain’s serotonin system. It belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). For men with PE, the serotonin levels might drop too quickly during sex. This may cause them to ejaculate too early.

Dapoxetine is a fast-acting SSRI. It works by blocking the reabsorption of serotonin by nerve cells. This causes an increase in available serotonin. The high levels of serotonin increase the time taken to ejaculate. This may help delay the release of semen long enough for satisfactory sexual intercourse.

Note that Sildigra Super Power 160mg does not cause an erection on its own. A person needs to be sexually stimulated for the medicine to work.

Uses

Recommended Dose

References

1. McMahon, C. G. (2002). High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction. International Journal of Impotence Research, 14(6), 533–538. https://doi.org/10.1038/sj.ijir.3900936 
2. Liu, K. K., Sakya, S. M., O’Donnell, C. J., Flick, A. C., & Li, J. (2011). Synthetic approaches to the 2009 new drugs. Bioorganic & Medicinal Chemistry, 19(3), 1136–1154. https://doi.org/10.1016/j.bmc.2010.12.038 
3. Hatzimouratidis, K. (2006c). Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical Interventions in Aging, 1(4), 403–414. https://doi.org/10.2147/ciia.2006.1.4.403 
4. Tuken, M., Culha, M. G., & Serefoglu, E. C. (2019b). Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction—DAP-SPEED Study. International Journal of Impotence Research, 31(2), 92–96. https://doi.org/10.1038/s41443-019-0122-2 
5. Kim, J. N., Oh, J. J., Park, D. S., Hong, Y. K., & Yu, Y. D. (2019). Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sexual Medicine, 7(4), 425–432. https://doi.org/10.1016/j.esxm.2019.07.004
6. El-Hamd, M. A., & Abdelhamed, A. (2017). Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. Andrologia, 50(1), e12829. https://doi.org/10.1111/and.12829