Ivermectin Tablet

Ivermectin is an anti-parasitic drug that treats certain infectious diseases caused by parasites like roundworms. It is a type of medication known as anthelmintics, used to destroy “helminths,” worm-like parasites. The family of the drug is “avermectin”.

Ivermectin kills specific parasites by either paralyzing them or starving them. It is generally used to treat parasitic infections of the eyes, skin, and intestinal tract. The treatment is known as “deworming”.

Ivermectin should not be used to treat any bacterial or viral diseases. Do not use it for COVID-19 unless you participate in a clinical study.

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How Does Ivermectin Tablet Work

  • Ivermectin comes under the avermectin class of medicines. It has potent anthelmintic and insecticidal properties.
  • Ivermectin destroys parasitic worms by opening chloride channels that are sensitive to glutamate (the neurotransmitter).
  • This prevents their nervous system from working.
  • By targeting the nervous system, the drug causes paralysis and as a result, kills the parasites.

Uses of Ivermectin Tablets

  • Cures parasite infections, e.g., hookworm and threadworm infestation, river blindness (onchocerciasis), roundworm infestation (e.g., strongyloidiasis), filariasis (a mosquito-borne infection), loiasis (skin and eye disease)
  • Used for the treatment of scabies (skin rash caused by mites)
  • The topical cream with this ingredient treats head lice. It also helps with skin conditions such as rosacea (appears as a red rash on the nose and cheeks)
  • Prevents the infection from turning fatal
  • It kills both endoparasites and ectoparasites, so it’s termed as “the world’s first endectocide”.
  • Improves quality of life and promotes health and well-being.

Dosage

Take Ivermectin as per your physician’s advice because it’s based on the type of infection, your weight, and your age. The tablet is to be swallowed with one full glass of water on an empty stomach. In case you’re unable to swallow it whole, you may cut it into two. However, the usual recommended Ivermectin doses for some infections are as follows:

  • Adult dose for Onchocerciasis-  3 mg once (weight: 15-25 kg); 6 mg one time (weight: 26-44 kg); 9 mg once (weight: 45-64 kg); 12 mg once (weight: 65-84 kg); 0.15 mg/kg (weight: >85 kg).
  • Adult dose for Strongyloidiasis- 3 mg once (weight: 15-24 kg); 6 mg one time (weight: 25-35 kg); 9 mg once (weight: 36-50 kg); 12 mg once (weight: 51-65 kg); 15 mg once (weight: 66-79 kg); 0.2 mg/kg (weight: >80 kg).
  • Adult dose for Filariasis- 0.2 mg/kg body weight one time
  • Adult dose for Ascariasis- 0.2 mg/kg body weight one time
  • Adult dose for Scabies- 0.2 mg/kg body weight one time (repeat after two weeks)
  • Adult dose for Cutaneous Larva Migrans- 0.2 mg/kg body weight one time (for 1 or 2 days)
  • Adult dose for Trichuriasis- 0.2 mg/kg body weight once daily (3 days)
  • Adult dose for parasite infection of eyes and skin- 0.15mg/ kg one time (follow up with your doctor for additional dose)

Missed Dosage

Ivermectin is usually a single-dose medication, so there are rare chances of you missing a dose.

However, if you’re using a series of doses as prescribed by your doctor, and you miss a dose, take it as soon as you remember. If it’s about time for the next dose, skip the missed dose and only take the former. Do not take two doses at once.

Do not take Ivermectin more than or less than as advised by your doctor. Do not stop or change the dosage options without a doctor’s approval. Incorrect dosing can lead to anthelmintic resistance and failure in treatment.

Overdose

If you happen to have overdosed on the drug, get medical help. You may face mild to serious side effects, depending on how much Ivermectin you’ve taken. Some symptoms include skin rashes, headache, vomiting, dizziness, diarrhea, and seizures. Overdose can cause neurotoxicity, which can be fatal.

Safety Advice

Other Precautions

Let your doctor know about any health condition you are suffering from or have suffered from in the past.

  • If you are allergic to Ivermectin or any of the tablet’s inactive ingredients
  • If you have a history of liver-related problems
  • If you experience or have had seizures
  • If you have been diagnosed with HIV or any other condition that lowers your immunity
  • If you suffer from asthma
  • Certain parasite infections, e.g., Loa loa should not be used with this treatment.

Side effects of Ivermectin tablets

We still need more data regarding the efficacy or safety of this drug. However, current evidence shows few adverse effects.

Some common Ivermectin side effects are:

  • Tiredness or exhaustion
  • Loss of appetite
  • Nausea
  • Dizziness
  • Stomach pain
  • Joint pain
  • Tender lymph nodes
  • Fever
  • Eye problems

The common symptoms will go away in a few days on their own.

Severe side effects are rare (maybe the result of an overdose) and may include:

  • Neck and back pain
  • Redness and swelling in eyes
  • Changes in vision
  • Shortness of breath
  • Seizures
  • Confusion
  • Urinary problems (can’t control urine) and bowel movement issues
  • Dark urine
  • Extreme fatigue
  • Coma

In some people, Ivermectin can cause a serious allergic reaction. Symptoms include skin rash, swollen tongue and/or throat, and difficulty in breathing.

In case you see a symptom that doesn’t go away or concerns you, seek medical attention.

Interaction With Other Drugs

Certain medications and substances (e.g., herbs and supplements) may alter the way Ivermectin works. Let your doctors know about drugs/supplements you consume often or regularly. 

These may include: 

  • Blood-thinning drugs like warfarin
  • Barbiturates like phenobarbital and butalbital
  • Benzodiazepines like clonazepam and lorazepam
  • Sodium oxybate (GHB)
  • Valproic acid
  • Rifampin
  • Ritonavir
  • Erythromycin
  • Ketoconazole
  • Cyclosporin
  • Quinidine
  • Verapamil

This list doesn’t contain all the drug interactions, so tell your doctor about any other medicine you might be taking.

Interaction With Alcohol

Consumption of alcohol (and marijuana) is known to increase the drug level in your blood plasma. So, it can make you dizzy. Do not drive while in this condition. Try to limit alcohol consumption.

Interaction With Grapefruit Juice

Grapefruit or its juice may hinder Ivermectin’s action, so avoid consuming it while on this medication.

Storage Instructions

Store the Ivermectin tablets in their original packaging at room temperature (86 degrees F/30 degrees C. Do not expose them to direct light or moisture, as it may damage the drug. Dispose of the expired tablets or empty packages properly. Keep it out of reach of the children.

References

  1. Sulik, M., Antoszczak, M., Huczyński, A., & Steverding, D. (2023). Antiparasitic activity of ivermectin: Four decades of research into a “wonder drug.” European Journal of Medicinal Chemistry, 261, 115838. https://doi.org/10.1016/j.ejmech.2023.115838
  2. Failoc-Rojas, V. E., Silva-Díaz, H., Maguiña, J. L., Rodriguez-Morales, A. J., Díaz-Velez, C., Apolaya-Segura, M., & Valladares-Garrido, M. J. (2023). Evidence-based indications for ivermectin in parasitic diseases: An integrated approach to context and challenges in Peru. Parasite Epidemiology and Control, 23, e00320. https://doi.org/10.1016/j.parepi.2023.e00320
  3. Clinical care of strongyloides. (2024, February 16). Strongyloides. https://www.cdc.gov/strongyloides/hcp/clinical-care/index.html#:~=Ivermectin%20and%20albendazole%20can%20treat,2%20%E2%80%93%204%20weeks%20after%20treatment.%20scabies
  4. Sanchezruiz, W. L., Nuzum, D. S., & Kouzi, S. A. (2018). Oral ivermectin for the treatment of head lice infestation. American Journal of Health-System Pharmacy, 75(13), 937–943. https://doi.org/10.2146/ajhp170464
  5. Crump, A., & Omura, S. (2011). Ivermectin, “Wonder drug” from Japan: the human use perspective. Proceedings of the Japan Academy Series B, 87(2), 13–28. https://doi.org/10.2183/pjab.87.13
  6. Zhao, Y., Gameiro-Ros, I., Glaaser, I. W., & Slesinger, P. A. (2021). Advances in targeting GIRK channels in disease. Trends in Pharmacological Sciences, 42(3), 203–215. https://doi.org/10.1016/j.tips.2020.12.002
  7. Hoang, R., Temple, C., Correia, M. S., Clemons, J., & Hendrickson, R. G. (2022). Characteristics of ivermectin toxicity in patients taking veterinary and human formulations for the prevention and treatment of COVID-19. Clinical Toxicology, 60(12), 1350–1355. https://doi.org/10.1080/15563650.2022.2134788
  8. Hoang, R., Temple, C., Correia, M. S., Clemons, J., & Hendrickson, R. G. (2022b). Characteristics of ivermectin toxicity in patients taking veterinary and human formulations for the prevention and treatment of COVID-19. Clinical Toxicology, 60(12), 1350–1355. https://doi.org/10.1080/15563650.2022.2134788
  9. Canga, A. G., Prieto, A. M. S., Liébana, M. J. D., Martínez, N. F., Vega, M. S., & Vieitez, J. J. G. (2008). The Pharmacokinetics and Interactions of Ivermectin in Humans—A mini-review. The AAPS Journal, 10(1), 42–46. https://doi.org/10.1208/s12248-007-9000-9
  10. Duthaler, U., Leisegang, R., Karlsson, M. O., Krähenbühl, S., & Hammann, F. (2019). The effect of food on the pharmacokinetics of oral ivermectin. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkz466
  11. Roche, D. J. O., Yardley, M. M., Lunny, K. F., Louie, S. G., Davies, D. L., Miotto, K., & Ray, L. A. (2016). A pilot study of the safety and initial efficacy of ivermectin for the treatment of alcohol use disorder. Alcoholism Clinical and Experimental Research, 40(6), 1312–1320. https://doi.org/10.1111/acer.13064
  12. ToxTalks. (2021). In IVERMECTIN (p. 2 of 3) [Report]. https://med.virginia.edu/toxicology/wp-content/uploads/sites/268/2021/10/Oct21-Ivermectin.pdf

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Frequently Asked Questions (FAQs)

Ans. Ivermectin is an antiparasitic drug that kills worms that cause infection. It works by either starving or paralyzing them. It is useful in the treatment of parasitic infections of the eyes, skin, and intestines. Some conditions that it treats are- scabies, head lice, Strongyloidiasis, and Onchocerciasis. Filariasis, Ascariasis, and Cutaneous larva migrans (creeping disease).
Ans. The FDA has authorized the use of ivermectin tablets to treat roundworm infections. However, some clinical studies indicate ivermectin can treat or manage COVID-19 in humans or animals.
Ans. The drug is quickly absorbed after being taken orally and reaches peak plasma concentration in 2 - 4 hours. You can expect to see the results within two days to 2 weeks of treatment.
Ans. The tablet should be taken on an empty stomach (or at least 1 hour after a meal). Refrain from having a meal at least 2 hours after taking it.
Ans. No, because it is a prescription medicine. We insist you not to self-medicate as the dosage has to be determined by a doctor. An overdose may cause severe side effects like seizures, difficulty in breathing, vomiting, and coma.
Ans. It is safe as long as you take it as per your physician’s prescription. Taking more of it will cause serious side effects.
Ans. The price of Ivermectin will vary depending on the dosage and brands. Generic Ivermectin is cheaper than the branded version..
Ans. Neither. This drug is not a steroid, and it's not an antibiotic. It's anthelmintic. The medicine is not used to kill bacteria. It's used to kill parasites.
Ans. However, the Food and Drug Administration (FDA) has not yet approved the use of oral tablets for lice. But, research shows that a single 200 mg/kg ivermectin dose can kill lice in children.
Ans. We need more studies on the safety and effectiveness of this drug in children with weight less than 15 kg. It's approved for certain conditions, e.g., scabies in children who weigh more than 15 kg. However, its off-label use includes children weighing less than 15 kg.
Ans. It's unlikely that your doctor will recommend you to take it every day or for a long time. However, the dosage options and directions depend on your medical condition. So, follow your prescription for optimal results.
Ans. Your liver metabolizes the drug. The unused amount of the drug and its metabolites are excreted via feces over 12 days. Less than 1% of the medication is flushed out of your body via urine.
Ans. You can use the topical cream on your skin. But these tablets are for oral administration.
Ans. The antiparasitic agent itself is not known to cause any heart problems. However, it can increase heart rate and lower your blood pressure. However, seek medical guidance if you have heart conditions, e.g., cardiac arrhythmia and myocardial dysfunction, before use.

Ivermectin Tablet
Ivermectin Tablet
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