One of my favorite supplements, Nicotinamide Riboside (NR), is now available at the AIM Center as an IV! NR is a naturally occurring compound that has recently garnered attention for its potential to support cellular health, longevity, and overall wellness. While it is typically ingested in supplement form, the intravenous (IV) administration of NR is an innovative method to rapidly boost its effectiveness. In this blog post, we will explore the science behind IV Nicotinamide Riboside, its benefits, and the evidence supporting its use.

What is Nicotinamide Riboside (NR)?

Nicotinamide Riboside (NR) is a form of vitamin B3, also known as niacin. NR plays a crucial role in the body’s ability to produce NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme that is in

volved in several key cellular processes, including energy production, DNA repair, and the regulation of circadian rhythms. As we age, our NAD+ levels naturally decline, which can contribute to the aging process and the onset of age-related diseases.

Why IV Nicotinamide Riboside?

Typically, NR is taken orally, but oral absorption may be limited by factors like digestion and bioavailability. By delivering NR directly into the bloodstream, the body can bypass the digestive system, ensuring that the compound reaches cells faster and more efficiently. This method allows for higher concentrations of NR to be delivered, potentially enhancing its effectiveness.

The Key Benefits of IV Nicotinamide Riboside

1. Boosts NAD+ Levels: The primary benefit of IV NR is its ability to rapidly increase NAD+ levels in the body. NAD+ is essential to help regulate cellular processes like aging, inflammation, and stress resistance.
2. Enhances Mitochondrial Function: The function of mitochondria, the powerhouses of the cell, naturally declines as we age, which can lead to reduced energy levels, increased fatigue, and decreased muscle performance. Research has shown that increasing NAD+ levels via NR supplementation can enhance mitochondrial function, improving energy production and reducing the effects of agingon muscle performance.
3. Improves Cognitive Function: NAD+ plays a significant role in brain health. Research has shown that boosting NAD+ levels can enhance cognitive performance and may help prevent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. IV NR therapy, could have a noticeable impact on mental clarity, focus, and memory retention.
4. Promotes Healthy Skin and Delays the Aging Process: NAD+ has been shown to promote healthy skin by enhancing the repair and regeneration of skin cells. As NAD+ levels increase, it may help protect the skin from oxidative damage, reduce the appearance of fine lines, and improve overall skin tone.

IV NR & Mast Cell Activation Syndrome (MCAS)

Research has shown that NAD+ influences several aspects of immune system regulation, including the activity of mast cells. By supporting proper cellular signaling, IV NR may help reduce the sensitivity of mast cells to triggers and prevent unnecessary activation, potentially alleviating MCAS symptoms such as skin rashes, headaches, and gastrointestinal distress. IV NR has become a staple supportive treatment for MCAS patients.

Seeking a diagnosis for MCAS can be challenging, especially when many doctors are unfamiliar with Mast Cell Activation Syndrome. A common question we receive is, “How can we effectively present our MCAS case to ensure that doctors understand and listen?” Click here for tips to help you make the most out of your doctor’s appointment when being evaluated for Mast Cell Activation Syndrome.

Why Choose Our IV Therapy?

One of my favorite new IV therapies, IV Nicotinamide Riboside, holds tremendous potential in supporting cellular health, enhancing mitochondrial function, and slowing down the effects of aging. With its ability to rapidly boost NAD+ levels, this treatment may have wide-ranging benefits, from improved energy levels and cognitive function to healthier skin and DNA repair. Whether you’re struggling with chronic health concerns, or looking to optimize your routine, IV NR is a great option for everyone.

We’re now offering an IV formula from the makers of Tru Niagen, the trusted brand behind nicotinamide riboside (NR) supplements. If you’ve been taking NR capsules, this IV version provides even faster absorption and a more potent effect—giving your cells exactly what they need to function at their best. For more information, please click here or to schedule an appointment, please call the office at +1 (914) 730-7390.

References

1. Bogan, K. L., & Brenner, C. (2008). Nicotinamide riboside: a boost to NAD+ metabolism. Trends in Biochemical Sciences, 33(1), 1-3. [DOI: 10.1016/j.tibs.2007.11.002]
2. Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: The biology and therapeutic potential of NAD+ metabolism. Cell Metabolism, 27(3), 529-547. [DOI: 10.1016/j.cmet.2018.02.015]
3. Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013). NAD+ metabolism: A therapeutic target for age-related metabolic disease. Critical Reviews in Biochemistry and Molecular Biology, 48(1), 57-87. [DOI: 10.3109/10409238.2012.742217]
4. Finkel, T., & Holbrook, N. J. (2000). Oxidants, oxidative stress, and the biology of aging. Nature, 408(6809), 239-247. [DOI: 10.1038/35041687]
5. Gehrke, S., & Canto, C. (2021). NAD+ and its role in immune cell metabolism and function. Immunological Reviews, 296(1), 125-136. [DOI: 10.1111/imr.12913]