Silodosin Capsule

Active Ingredient	Silodosin
Type	Enlarged Prostate or Benign Prostatic Hyperplasia (BPH)

How does Silodosin work?

Enlargement of the prostate squeezes the urethra, resulting in problems with urination. Silodosin belongs to the category of alpha-1 blockers, which is an adrenoceptor antagonist that works specifically on the alpha-1 receptors in the prostate and bladder tissue. Silodosin capsules block these receptors, which relax the muscles in the bladder and prostate to ease the symptoms.

Uses of Silodosin Capsules

These oral use capsules are effective in the management of the below-listed symptoms of BPH when taken properly:

• Frequent and sudden urge to urinate.
• Nocturia – nighttime urination 
• Decreased urine flow
• Strained urination
• Leakage after urination
• Feeling as if you cannot empty your bladder

Dosage

This generic medication is available in two strengths, 4 milligrams, and 8 milligrams, and is a long-term treatment for managing BPH-associated symptoms. The doctor will decide the exact dosage based on your age, type of symptoms and severity, and any other ailments you may have.

• These capsules are recommended to be taken once every day with a meal.
• The dose must be taken around the same time every day for the most effective outcomes.
• Do not consume these tablets on an empty stomach, which increases the likelihood of side effects.

Missed Dosage

When you miss a dose, it is recommended that you take it as soon as you remember. However, if you remember that it’s time for your next dose, do not consume the missed dose and continue with the next dose. Do not consume two capsules to compensate for the missed one, which may result in serious side effects.

Overdose

Overdosing with Silodosin capsules may lower blood pressure. You may feel the following symptoms, especially when you stand up after lying down or sitting. 

• Weakness
• Feeling lightheaded
• Losing consciousness
• Blurring of vision
• Confusion

Seek immediate medical assistance if you feel any of these symptoms.

Important Advisory

Silodosin capsules may not be suitable for use in some health conditions. Talk to your doctor if you suffer from the following disorders.

• Do you have any known allergies to Silodosin or any other ingredients in the capsules?
• Hypotension – as these capsules lower the blood pressure, unsupervised use may result in further lowering, leading to serious health issues.
• Kidney disorders – Silodosin capsules are not administered in cases of severe kidney disorders, and low doses are advised for moderate kidney disease.
• Liver disease – as the liver is responsible for the metabolization of this drug, it is not administered in those who suffer from severe liver conditions. 
• Conditions related to eyes – glaucoma or cataract.
• If there is any history of hypotension, cardiovascular disease, or prostate cancer, take diuretics or consume a low-salt diet.

Note: This medication may cause dizziness, so do not drive or operate heavy machinery.

• This medication is not intended for use in women. There is no sufficient scientific evidence available to rule out the possibility of complications in the growing fetus inside the womb and a breastfeeding baby. 

Silodosin Side Effects

The mild side effects commonly encountered with the Silodosin tablet are listed below. These side effects disappear within a couple of days or weeks. However, if you feel they are worsening or not going away, talk to your doctor for appropriate treatment.

• Diarrhea
• Stuffy nose
• Common cold
• Dizziness
• Headache 
• Lowering of blood pressure when you stand up after lying down or sitting.
• Retrograde ejaculation

Interactions With Other Drugs

Some medications may react with other medications or some ingredients in over-the-counter supplements, which affects the way the medication will work. Silodosin capsules may interact with other prescription medications or supplements (some are listed below). Communicate to your doctor about all the medications, whether prescription or over-the-counter supplements, you may be taking to establish a safe method of administration.

• Ketoconazole
• Diltiazem
• Erythromycin
• Clarithromycin
• Ritonavir
• Saquinavir
• Alfuzosin
• Atazanavir
• Cyclosporine
• Terazosin
• Valsartan
• Clonidine
• Carvedilol
• Sildenafil
• Tadalafil

Interaction with Alcohol

Alcohol causes drowsiness or dizziness, and Silodosin also has a side effect where you may feel dizzy. Therefore, alcohol and Silidosin are not a favorable combination. You should avoid the use of alcohol or at least limit it to the minimum to avoid any adverse side effects.

Interaction with Grapefruit Juice

Grapefruit may increase the amount of Silodosin in the body, thus increasing the chances of adverse effects. Consult your physician to discuss if the grapefruit products may impact you in any way.

Storage Instructions

Silodosin capsules should be stored in a cool and dry place with a temperature not exceeding 86 degrees Fahrenheit.

• Ensure that the tablets are stored away from a source of light.
• Store the capsules at a safe distance from the reach of children. 
• After opening the pack, store it in an airtight container to protect it from moisture.
• Don’t consume the tablets past their expiry date, and dispose of them safely.

Frequently Asked Questions (FAQs) 

Q1. What are Silodosin capsules used for?

The Silodosin capsules are used for the treatment of Benign Prostatic Hyperplasia (BPH) or enlarged prostate in men. They work effectively to manage the symptoms like frequent and sudden urination, nocturia, painful urination, and other symptoms.

Q2. What is the recommended dosage of Silodosin?

Silodosin is available in two strengths of 4 milligrams and 8 milligrams. The exact dosage depends on your age, the symptoms you are experiencing and their severity, and also any other health condition you may have. Usually, the doctors prescribe a lower strength of 4 mg to supervise how your body reacts to this medication. The commonly prescribed adult dosage (18 to 64 years) is 8 mg. A dose of 4 mg is advised for people above 64 years of age because metabolization by the liver and removal of the residue by kidneys slow down with age, thus increasing the possibility of side effects.

Q3. What can I do if I’m not able to consume a capsule?

If you do not feel comfortable swallowing the capsule, you can open it, sprinkle the contents on a spoon full of applesauce, and consume it. Make sure that the applesauce is not hot and that you consume it within 5 minutes. Do not store any of this mixture for future use. 

Q4. Are Silodosin capsules safe for consumption on an empty stomach?

When consumed on an empty stomach, the chances of side effects are higher. Therefore, it is recommended to take the tablet orally with a meal.

Q5. What symptoms should I watch out for when using Silodosin capsules?

Contact your doctor for medical advice if you feel your blood pressure lowering or develop any unusual symptoms after using these capsules. Seek immediate help in case of an allergic reaction.

Q6. How long does it take for Silodosin to show improvement in managing symptoms?

The Silodosin capsules must be taken every day around the same time to effectively manage BPH symptoms. This treatment is for the long term, and you will start to see improvement in ease of urination. If you do not feel any progress in symptoms, talk to your doctor.

Q7. Are there any dietary modifications that are required to be made when using Silodosin capsules?

Consult your doctor about consuming grapefruit and alcohol in your diet. Your doctor may advise you to reduce your fluid intake around the evening, but no other dietary modifications are required for the treatment with Silodosin. 

References

1. https://pubmed.ncbi.nlm.nih.gov/30523608/
2. https://pubmed.ncbi.nlm.nih.gov/30098325/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131986/