Edegra 100 mg Tablet

Manufacturer	Sun Pharmaceutical Industries Ltd
Active Ingredient	Sildenafil Citrate
Starts In	30 minutes to 1 hour
Lasts Long	4-5 hours
Type	Erectile Dysfunction

How Does It Work?

Edegra 100 mg contains Sildenafil Citrate, which belongs to a group of drugs known as PDE 5 inhibitors. It blocks the action of the enzyme PDE 5 (Phosphodiesterase Type 5) and enhances the effects of nitric oxide, thereby improving blood flow to the penis.
When a person is sexually stimulated, a chemical known as nitric oxide is released into the penis. This chemical triggers a chain of reactions. Nitric oxide interacts with the haem group of the enzyme soluble guanylate cyclase (sGC) and stimulates the production of cGMP. cGMP, or cyclic guanosine monophosphate, regulates the contraction and dilation of blood vessels that carry blood to and from the penis. Edegra stops the enzyme PDE 5 from destroying cGMP and allows the blood to flow properly to the penis. As more blood flows to the penis, pressure is created, and the two chambers of the penis (known as corpora cavernosa) get filled with blood. This leads to an erection.

Uses

Edegra 100 mg is prescribed for the treatment of the following conditions:
Erectile Dysfunction (ED) – also known as impotence, makes a man unable to achieve or sustain an erection firm enough for sexual intercourse. It occurs due to decreased blood flow to the penis caused by physical and psychological problems.

Dosage

The recommended dose of Edegra 100 mg is one tablet per day. You should not consume more than one tablet within a 24-hour window. It can be taken with or without food. However, for best results, it should be taken on an empty stomach, as some fatty foods can delay the absorption process of the drug. It is recommended to take the pill an hour before sexual activity begins. This is an on-demand drug. The effects of this pill can be experienced within an hour of its consumption. However, this may vary from person to person depending on age, metabolism, existing health conditions, medications, etc.

Missed Dose: This medicine is taken when required. Therefore, you’re less likely to miss a dose. Make sure that you’re sexually stimulated for this pill to work properly.

Overdose: Overdosing can lead to adverse side effects. In case of an overdose, seek medical help immediately.

Important Advisory

Edegra 100 mg may not suit you if you suffer from any medical conditions mentioned below. Before you take this medicine, let your doctor know:

• If you are allergic to Sildenafil Citrate or any other medications.
• If you have a history of stroke, congestive heart failure, etc.
• If you suffer from blood cell problems such as sickle cell anemia, leukemia, multiple myeloma, etc.
• If you suffer from kidney or liver disease.
• If you have a physical deformity of the penis or Peyronie’s.
• If you have uncontrolled blood pressure.
• If you suffer from conditions such as diabetes, high blood cholesterol, etc.
• If you have an eye-related condition such as retinitis pigmentosa.
• If you take nitrates for chest pain.
• If you suffer from epilepsy or seizures.
• If you are pregnant or breastfeeding.
• If you suffer from ischemic heart disease.
• If you are an alcoholic or have a history of substance abuse.

If you suffer from any medical conditions not listed here, let your doctor know about them. Discuss your medical history in detail with the doctor.

Side effects of Edegra 100 mg

Edegra can come with certain side effects. Most of the side effects are temporary and go away after some time. Some of the commonly reported side effects include:

• Headaches
• Nausea
• Flushing
• Dizziness
• Diarrhea
• Indigestion
• Sleeplessness
• Bloody and cloudy urine
• Visual disturbances
• Nasal congestion
• Painful urination
• Sensitivity to light
• Burning, numbness, or tingling in the arms and feet

Some rare side effects of the medication include:

• Chest pain
• Trouble breathing
• Decrease/ loss of hearing
• Decrease/ loss of vision
• Priapism (a prolonged and painful erection of more than 4 hours)

The above list shouldn’t be seen as a complete guide to side effects. If you experience any other side effects of the medication, report it to the doctor.

Drug Interactions

If you take any prescription or non-prescription medications or any vitamins and herbal supplements, let your doctor know about them. Certain medications can interact with Edegra 100 mg and alter how it works. Here is a list of drugs that can interact with Edegra 100 mg.

• Antibiotics such as clarithromycin
• Oral antifungals such as ketoconazole
• HIV drugs such as ritonavir and indinavir
• Amlodipine
• Seizure medications such as carbamazepine
• Nitroglycerin
• Alpha-blockers such as doxazosin and terazosin
• Beta-blockers such as atenolol
• Dexamethasone
• Imatinib Mesylate
• Isoniazid
• Blood thinners such as warfarin
• Other medicines for ED

This isn’t a complete list of potential drug interactions. Discuss possible drug interactions with your doctor before starting this medicine.

Interaction with alcohol

Alcohol increases the risk of adverse side effects and reduces the chances of getting an erection. Drinking alcohol alongside Edegra 100 mg is not advised.

Interaction with grapefruit juice

Grapefruit juice contains furanocoumarins that increase the likelihood of adverse side effects. It also raises the levels of Edegra in the body and delays the time it takes for the medication to work. Therefore, it should not be consumed while taking Edegra 100 mg.

Storage Instructions

• These pills should be kept out of the reach of children and pets.
• Keep the pills away from direct heat, moisture, and sunlight.
• If the pack has expired, do not consume the pills.
• Keep these pills in a cool and dry place.

Substitutes Available

Aurogra 100 mg
Suhagra 100 mg
Fildena 100 mg
Viagra 100 mg

Frequently Asked Questions (FAQs)

Q. How long does Edegra last?

Ans. The effects of Edegra usually last for 4-5 hours. However, this may vary from person to person depending on age, metabolism, medications, etc. The effects of this medicine can be experienced within one hour of its consumption. Do not take a heavy meal before taking this medicine, as it may slow down the onset of the medication.

Q.Is Edegra safe?

Ans. Yes! This medicine is considered safe and effective for use in ED patients. However, it should be used cautiously in patients suffering from kidney or liver diseases. It can also harm patients taking nitrates or blood pressure medications as the interaction can cause a sudden drop in blood pressure, which can be fatal.

References

• Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2002 Jun 24;162(12):1349-60. doi: 10.1001/archinte.162.12.1349. PMID: 12076233. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/211714
• Loran OB, Ströberg P, Lee SW, Park NC, Kim SW, Tseng LJ, Collins S, Stecher VJ. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med. 2009 Oct;6(10):2826-35. doi: 10.1111/j.1743-6109.2009.01428.x. PMID: 19817982. https://www.jsm.jsexmed.org/article/S1743-6095(15)32273-6/fulltext
• Smith BP, Babos M. Sildenafil. [Updated 2022 May 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558978/
• Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, Simonneau G; Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med. 2005 Nov 17;353(20):2148-57. doi: 10.1056/NEJMoa050010. Erratum in: N Engl J Med. 2006 Jun 1;354(22):2400-1. PMID: 16291984. https://www.nejm.org/doi/full/10.1056/NEJMoa050010
• Sofikitis N, Kaltsas A, Dimitriadis F, Rassweiler J, Grivas N, Zachariou A, Kaponis A, Tsounapi P, Paterakis N, Karagiannis A, Skouros S, Giannakis I, Champilomatis I, Paschopoulos M, Daphnis D, Giakoumakis I, R Gabales M, M Chua JB, Lantin Iii PL, Mamoulakis C, Takenaka A. The Effect of PDE5 Inhibitors on the Male Reproductive Tract. Curr Pharm Des. 2021;27(23):2697-2713. doi: 10.2174/1381612826666200226121510. PMID: 32101115. https://www.eurekaselect.com/article/104866
• Kim JN, Oh JJ, Park DS, Hong YK, Yu YD. Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sex Med. 2019 Dec;7(4):425-432. doi: 10.1016/j.esxm.2019.07.004. Epub 2019 Aug 20. PMID: 31444051; PMCID: PMC6963111. https://linkinghub.elsevier.com/retrieve/pii/S2050116119300935

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